Generate closed-loop circular DNA and RNA models

Sequence Requirement: A minimum of 30 base pairs is required to close the circular loop smoothly without steric clash.
Enter Sequence

Supports raw sequence or multiplier shorthand (e.g., A25G25T25C25).

Upload Sequence File
Click or drop FASTA / SEQ file here No file chosen

Supported: .fasta, .fa, .seq, .txt (For multi-FASTA, backend extracts 1st record; Max 8 MB).

Number of times to repeat the expanded sequence.
Backbone Conformation:
Backbone Optimization:
(Regularizes backbone stereochemistry while preserving base orientation)
wDSSR is developed by Drs. Shuxiang Li and Xiang-Jun Lu, and supported by NIH grant R24GM153869.
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